The 'Iron Man' star danced onto the stage at the ceremony at Universal Studios in Universal City, California to pick up the Hero Award from Colin Farrell, embracing him in a hug as he addressed the star-studded crowd.
Other winners on the night included Nicolas Cage, who was presented with the Maverick Award by director Quentin Tarantino, and Natalie Portman, who picked up Best Fantasy Actress for her role in 'Black Swan.'
'Harry Potter' star Daniel Radcliffe won the male equivalent at the awards, which applaud the best in fantasy, sci-fi, comics and horror, while Bradley Cooper collected the Best Thriller trophy for his film 'Limitless.'
Chloe Moretz picked up the award for Best Horror Actress from her pal "Teen Wolf" star Tyler Posey. She tweeted after the show, "So excited about winning #besthorroractress & #Letmein winning #besthorrormovie at the #ScreamAwards2011! Especially @tylergposey presenting."
Best Fantasy Movie went to 'X-Men: First Class,' Best Director was awarded to Darren Aronofsky for 'Black Swan,' and "Game of Thrones" was hailed Best TV Show.
The 2011 Scream Awards air Tuesday, October 18 on Spike.
The complete list of winners at the 2011 Scream Awards:
The Ultimate Scream - Harry Potter and the Deathly Hallows Part 2
Best Science Fiction Movie - Super 8
Best Fantasy Movie - X-Men: First Class
Best Horror Movie - Let Me In
Best Thriller – Limitless
Best TV Show - Game of Thrones
Best Director - Darren Aronofsky, Black Swan
Best Scream-Play – Harry Potter and the Deathly Hallows Part 2
Best Chase Scene – Chase Through London in Pirates of the Caribbean: On Stranger Tides
Best Fantasy Actress - Natalie Portman, Black Swan
Best Fantasy Actor - Daniel Radcliffe, Harry Potter and the Deathly Hallows Part 2
Best Science Fiction Actress - Milla Jovovich, Resident Evil: Afterlife
Best Science Fiction Actor - Matt Smith, Doctor Who
Best Horror Actress - Chloe Grace Moretz, Let Me In
Best Horror Actor - Alexander Skarsgård, True Blood
Best Villain - Ralph Fiennes, Harry Potter and the Deathly Hallows Part 2
Best Superhero - Chris Evans as Captain America
Best Supporting Actress - Mila Kunis, Black Swan
Best Supporting Actor - Peter Dinklage, Game of Thrones
Breakout Performance Male - Joe Manganiello, True Blood
Breakout Performance Female - Emilia Clarke, Game of Thrones
Best Cameo - Hugh Jackman, X-Men: First Class
Best Ensemble - True Blood
Most Memorable Mutilation - Scalped Alive By Motorboat, Piranha 3D
Fight Scene - Scott Pilgrim vs. The World
Holy Sh!t Scene of the Year - Harry Potter and the Deathly Hallows Part 2
Best Independent Movie – Monsters
Best 3D Movie – Transformers: Dark of the Moon
Best F/X - Harry Potter and the Deathly Hallows Part 2
Best Graphic Novel or Comic Book - The Walking Dead
Best Comic Book Writer - Ed Brubaker, Captain America
Best Comic Book Artist - John Romita, Jr., Avengers, Kick-Ass 2
Best Comic Book Movie - Scott Pilgrim vs. The World
Most Anticipated Scream - The Dark Knight Rises