Besides the fact that it's risky to do drugs in public with cameras around, the E! reality star split with her former husband Lamar Odom due to his reported drug problems.
TMZ posted a photo of Khloe smoking a blunt-like object at the club, but the 29-year-old took to her Twitter Tuesday night to clear the air, claiming it wasn't weed.
"Big difference between a hookah stick and weed...#DumbDumbs," she explained, before adding: "Ok I'm back on my 'Don't sweat the small stuff' sh*t lol starting......NOW"
She also Instagrammed this photo collage of her night out, where The Game seems to be smoking the same object Khloe was.
"So much fun!" she captioned the shot. Just not the illegal kind, apparently!